Para-Substituted Functionalised Ferrocene Esters with Novel Antibacterial Properties
Published: February 1, 2018 | DOI: https://doi.org/10.7860/JCDR/2018/30149.11218
Kevin Muñoz Forti, Faviola Bernard, Gustavo Santiago-Collazo, Waldemar Garcia, Jose L Vera, Enrique Meléndez, Edu B Suarez-Martinez
1. Graduate Student, Department of Biotechnology, Pontifical Catholic University of Puerto Rico, Ponce PR 00731;
Research Coordinator, Department of Biology, University of Puerto Rico, Ponce PR 00716.
2. Student, Department of Biology, University of Puerto Rico, Ponce PR 00716.
3. Student, Department of Biology, University of Puerto Rico, Ponce PR 00716.
4. Technician, Department of Biology, University of Puerto Rico, Ponce PR 00716.
5. Professor, Department of Chemistry, University of Puerto Rico, Mayagüez PR 00681;
Inter American University of San German Biology, Chemistry, and Environmental Science Department Calle Luna, San Germán 00683.
6. Professor, Inter American University of San German Biology, Chemistry, and Environmental Science Department Calle Luna, San Germán 00683.
7. Professor, Department of Biology, University of Puerto Rico, Ponce PR 00716; Professor, Ponce Research Institute, Ponce Health Sciences University, Ponce, Puerto
Rico 00732.
Correspondence
Dr. Edu B Suarez-Martinez,
Professor, Department of Biology, University of Puerto Rico, PO Box-7186, Ponce-00732, Puerto Rico.
E-mail: edu.suarez@upr.edu
Introduction: Bacterial antibiotic resistance is on rise despite advances in the development of new antibiotics. In an attempt to circumvent resistance, scientists are shifting focus from modifying existent antibiotics to identifying new antibiotic compounds.
Aim: To assess the potential antibiotic effects of functionalised ferrocenecarboxylates para-substituted on the phenoxy pendant group to form: 4-fluorophenyl, 4-chlorophenyl, 4-bromophenyl, 4-iodophenyl and 4-(H-pyrrol-1-yl)phenyl.
Materials and Methods: For this, we employed the Kirby-Bauer disc diffusion method using a collection of nine bacterial species: Staphylococcus aureus, Escherichia coli, Micrococcus luteus, Pseudomonas aeruginosa, Serratia marcescens, Klebsiella pneumoniae, Bacillus subtilis, Proteus vulgaris and Enterobacter aerogenes.
Results: The results show that all four-halogen substituted ferrocenecarboxylates 4-fluorophenyl (23.33 µM, 11.66 µM, 5.83 µM), 4-chlorophenyl (10.16 µM, 5.08 µM, 2.54 µM), 4-bromophenyl (9.0 µM, 4.5 µM, 2.25 µM), and 4-iodophenyl (17.12 µM, 8.56 µM, 4.28 µM) exhibited an antibacterial effect by reducing proliferation of Bacillus subtilis. Meanwhile, only 4-bromophenyl (9.0 µM) and 4-chlorophenyl (10.16 µM) ferrocenecarboxylates were able to decrease the growth of Micrococcus luteus.
Conclusion: Hence, functionalised ferrocenecarboxylates para-substituted with small and simple groups represent a novel class of bio-organometallic compounds with the potential to be used as antibacterial agents.
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